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'Me-too' pharma firms will 'disappear' - Roche's Schwan

World News | December 07, 2011
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Kevin Grogan

'Me-too' pharma firms will 'disappear' - Roche's Schwan

Drugmakers whose offerings do not offer any genuine value are going to "literally disappear" over the next decade, according to Roche's chief executive.

Speaking at the FT Pharmaceutical and Biotechnology conference in London, Severin Schwan (pictured) described a three-segment model with highly-innovative companies on one side and generics firm on the other. The number of players in the latter will be reduced through consolidation but the companies in the (middle) third segment, those that offer me-too treatments of "limited differentiation" will be squeezed out of business.

Their disappearance is inevitable, Dr Schwan said, given an environment where payers "will only reward true innovation". In terms of me-toos, he argued "who will pay for that? No money".

He began by saying that "pharma is in a perfect storm", with "the regulators' wind blowing in our face [and] investors breathing down our neck". He noted that payers are under enormous funding constraints while the sector is barely recouping the cost of its R&D spend.

Dr Schwan went on to say that in terms of pricing, there needs to be more differentiation and it has to be linked with actual benefit and real-world data needs to be combined with clinical data. However, on this topic, he asked "who is going to take the lead".

He also spoke of the importance of collaboration but acknowledged that "there is still distrust and both perceived and real conflicts of interest' that can make partnerships among the various stakeholders in healthcare "a real minefield". When asked about Roche's merger-and-acquisition strategy, Dr Schwan said that the firm is only interested in bolt-on deals and stressed the ever-increasing importance of its diagnostics division.

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  1. John Simolike 10 Dec

    I am not sure about Dr. Schwan's definition of what is a "me-too drug", so we may have areas of agreement. However, I disagree that pharmaceutical companies will shun "me-too drugs" in favor on innovative drugs.  Quite the opposite. Considering the the cost and time they must invest, due to the massive bureaucracy and maze regulations created by the FDA and its counterparts in other countries, pharmaceutical companies will more and more follow a strategy that favors  "me-too drugs" or drugs that are variations of existing drugs. This strategy will be less costly and less risky. Introducing an innovative therapy  is costly and risky.  Innovative drugs have a very uncertain payoff and if they are approved they are quickly followed by "me-too drug"competitors.



    If we want new, innovative drugs, I have two suggestions. First change the patent laws so that patent protection begins once the drug is approved, not way back at its inception, when it is discovered. The length of patent protection can be shortened from the current 17 years to another agreed length. This will create certainty that a drug's patent protection will not expire so soon after it is approved that return on the investment will be impossible.  Second, speed up the approval process by sreamlining regulatory review, forcing government bureaucrats  to speed up their work. Create an incentive for regulators to make decisions  for or against approval instaed of "kicking" the application back to the pharmaceutical company for more clarification or more studies. This will not only reduce the cost of drug approval and ultimately the cost of drug, most importantly it will save lives and reduce the suffering of the people whose afflictions the new drugs treat.

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